Neuropilin-2 Deficiency Promotes Mitochondrial Dysfunction and NAD⁺-Dependent Cellular Senescence in Retinal Degeneration
NRP2 is a critical regulator of mitochondrial integrity and NAD⁺ metabolism in the RPE. Its loss disrupts metabolic homeostasis, promoting RPE senescence and retinal degeneration. Targeting the NRP2-mitochondria-NAD⁺ axis with echinacoside represents a promising therapeutic strategy for preventing retinal degenerative diseases.
Authors
- Xialin Liu
- Baoyue Cui
- Linbin Zhou (ORCID: https://orcid.org/0000-0003-1572-336X)
- Tian Zhou (ORCID: https://orcid.org/0000-0001-5051-5182)
- Xuri Li (ORCID: https://orcid.org/0000-0002-8277-0767)
- Huiyi Xu (ORCID: https://orcid.org/0000-0001-7955-3772)
- Le Shi (ORCID: https://orcid.org/0000-0003-4827-4003)
- Lei Zeng
- Lechun Ou
- Yi Wei (ORCID: https://orcid.org/0000-0003-3993-9747)
- Yupeng Zheng (ORCID: https://orcid.org/0000-0002-2165-7859)
- Rong Ju
- Keli Liu
- Hong Zhou
- Chang He
- Feng Zhang
- Xiaolai Zhou
Institutions
- Johns Hopkins University (US)
- Sun Yat-sen University (CN)
- Chinese University of Hong Kong (HK)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2026-03-05
- DOI
- https://doi.org/10.1167/iovs.67.3.11
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00