Bidirectional Mendelian Randomization Analysis Reveals Causal Associations Between Autoimmune Diseases and Colorectal Cancer
This bidirectional MR study provides genetic evidence supporting unidirectional, modest causal effects of specific AIDs (CD and RA) on CRC risk. Further studies are warranted to clarify underlying mechanisms, including immune dysregulation, inflammation, and dietary factors, and to determine clinical implications.
Authors
- Xing Jin (ORCID: https://orcid.org/0009-0004-4716-6689)
- Guo Qiu Wu
- Chen Zhang (66790)
- Shuang Liu (8449)
- Kun Chen
- Xiao Yu Gu
- Yue Qi Wang
- Su Su Luo
- Zhi He
Institutions
- Second Military Medical University (CN)
- University of California San Diego (US)
- Zhongda Hospital Southeast University (CN)
- Eastern Hepatobiliary Surgery Hospital (CN)
- Southeast University (CN)
- Yangzhou University (CN)
Publication Details
- Journal
- World Journal of Oncology
- Published
- 2026-03-05
- DOI
- https://doi.org/10.14740/wjon2732
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Government of Jiangsu Province
- Southeast University