Sfrp2 in Microglia Inhibited S100a8-Mediated Neuroinflammation and Protected Neural Damage Following Retinal Ischemia-Reperfusion
Sfrp2 in microglia inhibits TRAF6-TAK1-NF-κB signaling pathway and downstream inflammatory mediator S100a8 thereby attenuating neuroinflammation and protecting the retina in I/R. Sfrp2 may represent a protective strategy for neuronal degeneration in ischemic retinopathy.
Authors
- YaGuang Hu
- Hui Xu (ORCID: https://orcid.org/0000-0001-5517-3556)
- Shuya Tao
- D. Ye
- Yan Xu (ORCID: https://orcid.org/0000-0003-0379-8866)
- Jun Huang (ORCID: https://orcid.org/0009-0006-8549-4098)
- Wen Hu
- Yuxun Shi
- Yantao Wei
- Fan Xu
- Qiaochu Cheng
- Zihao Lin
Institutions
- Sun Yat-sen University (CN)
- Guangxi Medical University (CN)
- First Affiliated Hospital of Guangzhou Medical University (CN)
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2026-03-05
- DOI
- https://doi.org/10.1167/iovs.67.3.8
- Primary Topic
- S100 Proteins and Annexins
- Type
- article
- Field-Weighted Citation Impact
- 0.00