Inhibition of GRK2 mitigates cisplatin‐induced acute and chronic nephrotoxicity by targeting the NADPH oxidase 4/oxidative stress axis
GRK2 plays a crucial role in cisplatin-induced nephrotoxicity by modulating NOX4, suggesting that targeting GRK2 is an effective renoprotective strategy for cisplatin-based cancer therapy.
Authors
- Jiajie Kuai (ORCID: https://orcid.org/0000-0001-9715-3975)
- Q. Edward Wang (ORCID: https://orcid.org/0009-0001-8333-2689)
- Fei Duan (ORCID: https://orcid.org/0000-0002-6490-0855)
- Shuoshuo Hu
- Wei Wei
- Chun Wang
- Jie Peng
- Bingfa Xu
- Xueru Wang
- Lei Ni
- Xiao Jiang
Institutions
- Anhui Medical University (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
- Second Affiliated Hospital of Anhui Medical University (CN)
- Hefei First People's Hospital (CN)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2026-03-05
- DOI
- https://doi.org/10.1111/bph.70348
- Primary Topic
- Chemotherapy-induced organ toxicity mitigation
- Type
- article
- Field-Weighted Citation Impact
- 0.00