ELABELA Protects Against Thoracic Aortic Dissection by Maintaining Vascular Smooth Muscle Cells Homeostasis and Regulating NETosis
We provide evidence that ELA prevents TAD progression and aortic medial degeneration, primarily by maintaining VSMC homeostasis, which may be linked to the inhibition of NETosis in neutrophils and NLRP3/IL-1β-related cellular signaling between VSMCs and neutrophils. ELA shows promise as a target for pharmacological therapy and diagnostic TAD management.
Authors
- Fen Zheng (ORCID: https://orcid.org/0000-0002-0783-7802)
- Juejin Wang
- Zhi Geng (ORCID: https://orcid.org/0000-0002-5764-6190)
- Qingguo Li (ORCID: https://orcid.org/0000-0002-2717-2908)
- Chao Ye (ORCID: https://orcid.org/0000-0002-9897-0085)
- Anyu Jiang
- Min Sha
- H. Shan
- Wei Hou
- Mingyu Hao
- Brain D. Susan
- Xiaoqing Xiong
- Aidong Chen
- Ying Zhou
Institutions
- Jiangnan University (CN)
- Xuzhou Medical College (CN)
- Nantong University (CN)
- London South Bank University (GB)
- The Affiliated Taizhou People's Hospital of Nanjing Medical University (CN)
- Second Affiliated Hospital of Nanjing Medical University (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Arteriosclerosis Thrombosis and Vascular Biology
- Published
- 2026-03-05
- DOI
- https://doi.org/10.1161/atvbaha.125.324169
- Citations
- 1
- Primary Topic
- Apelin-related biomedical research
- Type
- article
- Field-Weighted Citation Impact
- 32.57