Prolonged Extracorporeal Membrane Oxygenation Without Systemic Anticoagulation in Sheep
These preliminary findings suggest that the InFlo MOBYBOX may enable anticoagulant-free low-flow support with minimal thrombosis, hemolysis, and no organ injury, demonstrating the potential value of a multimodal approach using optimized fluidic pathways and a proprietary biopassive hydrophilic surface coating to advance safer extracorporeal therapies.
Authors
- Brian Y. Chang (ORCID: https://orcid.org/0000-0003-3067-2353)
- Alex Meng
- Nicholas X. Williams
- Zahra Mahdieh
Institutions
- Infinera (United States) (US)
- University of California San Diego (US)
- University of California, Irvine Medical Center (US)
- Massachusetts Institute of Technology (US)
Publication Details
- Journal
- Annals of Biomedical Engineering
- Published
- 2026-03-05
- DOI
- https://doi.org/10.1007/s10439-026-04053-5
- Primary Topic
- Mechanical Circulatory Support Devices
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Health and Human Services
- Biomedical Advanced Research and Development Authority