High-oxalate diet-induced kidney injury impairs AVF remodeling via hypertension, endothelial damage, and immune activation
The high-oxalate-induced chronic kidney injury-AVF model express key similarities to human impaired AVF remodeling, including long-term kidney failure, hypertension, endothelial damage and immune activation. By reducing animal burden and improving disease representation, this model advances preclinical AVF research towards greater translational applicability.
Authors
- Joris I. Rotmans (ORCID: https://orcid.org/0000-0001-9682-6234)
- Nicky Kruit (ORCID: https://orcid.org/0000-0002-6641-1254)
- P.H.A. Quax
- M.N. Nicese
- K. van Dijk
- E.P. de Winter
- A.H. Baker
- M. Goel
- M.R. de Vries
- H.A.B. Peters
- E.J. Snijder
Institutions
- Leiden University Medical Center (NL)
- British Heart Foundation (GB)
Publication Details
- Journal
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- Published
- 2026-03-05
- DOI
- https://doi.org/10.1016/j.bbadis.2026.168212
- Primary Topic
- Central Venous Catheters and Hemodialysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00