Efficacy and safety of adding immune checkpoint inhibitors to standard chemotherapy or chemoradiotherapy for advanced or recurrent cervical cancer: a meta-analysis

Adding ICIs to CT or CRT significantly improves survival outcomes in advanced or recurrent CC, particularly in PD-L1-positive patients. However, the increased risk of grade 3-5 AEs underscores the need for vigilant toxicity monitoring and management. These findings highlight the potential of ICIs to enhance immune-mediated tumor control, offering a promising therapeutic option for selected patient populations.

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Publication Details

Journal
Frontiers in Immunology
Published
2026-03-05
DOI
https://doi.org/10.3389/fimmu.2026.1780791
Primary Topic
Endometrial and Cervical Cancer Treatments
Type
article
Field-Weighted Citation Impact
0.00
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article

Efficacy and safety of adding immune checkpoint inhibitors to standard chemotherapy or chemoradiotherapy for advanced or recurrent cervical cancer: a meta-analysis

Chuntang Sun, Junchao Wang, Le Zhou, Peng Diao
Frontiers in Immunology
Endometrial and Cervical Cancer Treatments
article

Efficacy and safety of adding immune checkpoint inhibitors to standard chemotherapy or chemoradiotherapy for advanced or recurrent cervical cancer: a meta-analysis

Chuntang Sun, Junchao Wang, Le Zhou, Peng Diao
article en

Abstract

Adding ICIs to CT or CRT significantly improves survival outcomes in advanced or recurrent CC, particularly in PD-L1-positive patients. However, the increased risk of grade 3-5 AEs underscores the need for vigilant toxicity monitoring and management. These findings highlight the potential of ICIs to enhance immune-mediated tumor control, offering a promising therapeutic option for selected patient populations.

Frontiers in ImmunologyVol. 17
Sichuan University (CN), West China Second University Hospital of Sichuan University (CN), Guizhou Cancer Hospital (CN), Sichuan Cancer Hospital (CN), Ministry of Education (ET)
Good health and well-being
Openalex Percentile: Top 31%
Endometrial and Cervical Cancer Treatments
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