Efficacy and safety of adding immune checkpoint inhibitors to standard chemotherapy or chemoradiotherapy for advanced or recurrent cervical cancer: a meta-analysis
Adding ICIs to CT or CRT significantly improves survival outcomes in advanced or recurrent CC, particularly in PD-L1-positive patients. However, the increased risk of grade 3-5 AEs underscores the need for vigilant toxicity monitoring and management. These findings highlight the potential of ICIs to enhance immune-mediated tumor control, offering a promising therapeutic option for selected patient populations.
Authors
- Chuntang Sun
- Junchao Wang (ORCID: https://orcid.org/0000-0003-2560-8728)
- Le Zhou (ORCID: https://orcid.org/0000-0001-5891-4145)
- Peng Diao (ORCID: https://orcid.org/0009-0000-1097-1394)
Institutions
- Sichuan University (CN)
- West China Second University Hospital of Sichuan University (CN)
- Guizhou Cancer Hospital (CN)
- Sichuan Cancer Hospital (CN)
- Ministry of Education (ET)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-03-05
- DOI
- https://doi.org/10.3389/fimmu.2026.1780791
- Primary Topic
- Endometrial and Cervical Cancer Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00