Intestinal organoid screen reveals that Bacillus velezensis PGM541 promotes epithelial proliferation via its metabolite butyric acid
The probiotic strain PGM541, which was screened using intestinal organoids, promotes intestinal epithelial cell proliferation via its metabolite BA activating the FFAR2 receptor. These findings demonstrate that the intestinal organoid model serves as an effective platform for both preliminary probiotic screening and mechanistic investigation. Video Abstract.
Authors
- Lanmei Yin
- Qunbing Hu (ORCID: https://orcid.org/0000-0001-5830-9586)
- LI Jian-jun (ORCID: https://orcid.org/0000-0002-1592-4359)
- Xianglin Zeng
- Xiuyan Zheng
- Jing Huang
- Huansheng Yang
- Yan Tang
- Qiye Wang
Institutions
- Hunan Normal University (CN)
- Yanbian University (CN)
- Chinese Academy of Sciences (CN)
- Institute of Subtropical Agriculture (CN)
Publication Details
- Journal
- Microbiome
- Published
- 2026-03-05
- DOI
- https://doi.org/10.1186/s40168-026-02346-4
- Primary Topic
- Probiotics and Fermented Foods
- Type
- article
- Field-Weighted Citation Impact
- 0.00