Autophagy promotes the brain metastasis of cisplatin-resistant lung cancer cells through the KLF4/KLF2/IL15 signaling pathway
The autophagy-ATG5-KLF4/KLF2 axis may downregulate IL-15 in cisplatin-resistant lung cancer cells, suppressing NK cell activation and promoting brain metastasis. These findings offer useful insights into the mechanisms underlying the brain metastasis of lung cancer and provide valuable reference for the development of preventive and therapeutic strategies for this pathological condition.
Authors
- Jiying Wang (ORCID: https://orcid.org/0000-0001-9400-777X)
- Wentao Zhao (ORCID: https://orcid.org/0000-0002-9483-9004)
- Yong Cai
Institutions
- Tongji University (CN)
- Shanghai Pulmonary Hospital (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2026-03-05
- DOI
- https://doi.org/10.1186/s40001-026-04166-6
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.00