Expression of Bruton’s Tyrosine Kinase Reflects Immune Cells Infiltration and Cell Proliferation in Breast Cancer
BTK expression in BC reflects a proliferative and immune-active TME, particularly in TNBC and HER2-positive subtypes, but lacks prognostic or predictive value for NAC or PD-L1-based immunotherapy response.
Authors
- John M.L. Ebos (ORCID: https://orcid.org/0000-0002-7175-9044)
- Kohei Chida (ORCID: https://orcid.org/0000-0002-1318-5329)
- Kazuaki Takabe (ORCID: https://orcid.org/0000-0002-6435-4241)
- Kei Kawashima (ORCID: https://orcid.org/0000-0003-2503-9350)
- Rongrong Wu
- Tamrah AlRammah
- Takashi Ishikawa
Institutions
- Roswell Park Comprehensive Cancer Center (US)
- Fukushima Medical University (JP)
- Hirosaki University (JP)
- Tokyo Medical University (JP)
- Ministry of Health (SA)
- Cancer Genetics (United States) (US)
- University at Buffalo, State University of New York (US)
- Niigata University (JP)
- Yokohama City University (JP)
Publication Details
- Journal
- World Journal of Oncology
- Published
- 2026-03-05
- DOI
- https://doi.org/10.14740/wjon2708
- Primary Topic
- Chronic Lymphocytic Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Defense
- National Institutes of Health