Impact of Age at Onset on Relapse and Disability in AQP4-IgG Neuromyelitis Optica Spectrum Disorder
Our study demonstrates that while age at onset does not affect relapse risk, older patients experience more rapid disability accrual. These findings underscore the importance of early initiation of effective preventive immunotherapy in all age groups. The primary limitations of this study pertain to its retrospective design and the sole reliance on EDSS for disability assessment.
Authors
- Olga Mikhailovna Skibina (ORCID: https://orcid.org/0000-0001-5071-9345)
- Gregor Brecl Jakob (ORCID: https://orcid.org/0000-0003-4998-5974)
- Zbyšek Pavelek (ORCID: https://orcid.org/0000-0002-1772-8781)
- Zuzana Rous
- Saif Masharil Huda
- Tomáš Kalinčík (ORCID: https://orcid.org/0000-0003-3778-1376)
- Helmut Butzkueven (ORCID: https://orcid.org/0000-0003-3940-8727)
- Jihad Inshasi
- Raed Alroughani (ORCID: https://orcid.org/0000-0001-5436-5804)
- Miroslav Mareš
- Samia Joseph Khoury (ORCID: https://orcid.org/0000-0003-3198-6063)
- Marek Peterka (ORCID: https://orcid.org/0000-0002-0588-4592)
- Jorge Millán‐Pascual (ORCID: https://orcid.org/0000-0003-2112-5964)
- Ivana Štětkářová (ORCID: https://orcid.org/0000-0003-2699-1124)
- Jana Libertínová (ORCID: https://orcid.org/0000-0001-9737-0507)
- Barbara Willekens (ORCID: https://orcid.org/0000-0002-5212-8837)
- Eli Skromne
- Abdullah Rashid Al-Asmi (ORCID: https://orcid.org/0000-0002-2851-8157)
- Eva Havrdová (ORCID: https://orcid.org/0000-0002-9543-4359)
- Pakeeran Siriratnam (ORCID: https://orcid.org/0000-0003-4751-2102)
- Paul G. Sanfilippo (ORCID: https://orcid.org/0000-0002-1778-9154)
- Cecília Rajda (ORCID: https://orcid.org/0000-0002-0252-4778)
- V. Jokubaitis
- Jyh Yung Hor (ORCID: https://orcid.org/0000-0003-2244-879X)
- Andrea Surcinelli (ORCID: https://orcid.org/0000-0003-3779-0934)
- Recai Türkoğlu (ORCID: https://orcid.org/0000-0001-7685-4633)
- Singhal Bs
- Izanne Roos
- Cavit Boz
- A. Soysal
- Steve Vucic
- Guy Laureys
- Mark Slee
- Jiwon Oh
- Matteo Foschi
- Marta Vachova
- Tunde Csepany
- Talal Al-Harbi
- Stephen Reddel
- Orla Gray
- Ayse Altintas
- Guntis Karelis
- Jeannette Lechner Scott
- Allan G. Kermode
- Petra Nytrova
- Francesco Patti
- Magdolna Simo
- Jose E. Meca-Lallana
- Cristina Ramo-Tello
- Ilya Kister
- Seyed Mohammad Baghbanian
- Bassem Yamout
- Eva Recmanova
- Katherine Buzzard
- Vahid Shaygannejad
- Anneke Van Der Walt
- Sudarshini Ramanathan
- Chao Zhu
- Mehmet Fatih Yetkin
- Todd A. Hardy
- William M. Carroll
- Pavel Hradilek
- Enrique Gomez-Figueroa
- Jabir Alkhaboori
- Masoud Etemadifar
- Serkan Ozakbas
- Pamela Ann Mccombe
- Nevin Shalaby
- Francois Grand'Maison
- Jose Luis Sanchez Menoyo
- Richard Macdonell
- Abdorreza Naser Moghadasi
- for the MSBase Investigators
- Vincent van Pesch
- Farouk Talaat
- Marzena J. Fabis-Pedrini
- Mike Boggild
Institutions
- Semmelweis University (HU)
- Isfahan University of Medical Sciences (IR)
- The Royal Melbourne Hospital (AU)
- Koç University (TR)
- University Hospital Centre Zagreb (HR)
- University of Liverpool (GB)
- University of Ljubljana (SI)
- Karadeniz Technical University (TR)
- The University of Queensland (AU)
- Murdoch University (AU)
- University of Zagreb (HR)
- Charles University (CZ)
- University of L'Aquila (IT)
- Royal Brisbane and Women's Hospital (AU)
- Ghent University Hospital (BE)
- Ljubljana University Medical Centre (SI)
- The Alfred Hospital (AU)
- Sir Charles Gairdner Hospital (AU)
- Walton Centre (GB)
- Amiri Hospital (KW)
- University of Catania (IT)
- Bakırköy Psychiatric Hospital (TR)
- Ospedale "Santa Maria delle Croci" di Ravenna (IT)
- American University of Beirut Medical Center (LB)
- Hospital Civil de Guadalajara (MX)
- Policlinico Universitario di Catania (IT)
- Bombay Hospital (IN)
- Perron Institute for Neurological and Translational Science (AU)
- Hospital Universitario Virgen de la Arrixaca (ES)
- General University Hospital in Prague (CZ)
- Sultan Qaboos University (OM)
- Monash University (AU)
- Universidad Católica de Murcia (ES)
- Victoria University (AU)
Publication Details
- Journal
- Neurology
- Published
- 2026-03-05
- DOI
- https://doi.org/10.1212/wnl.0000000000214707
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00