An EV-Guided Multi-Compartment Proof-of-Concept Framework for Biomarker Prioritization in Cholangiocarcinoma
Rather than validating a single biomarker, this study presents an EV-guided, multi-compartment framework for prioritizing biomarker candidates at the discovery stage. By explicitly accounting for tumor heterogeneity and compartment-specific signal preservation, this proof-of-concept approach provides a practical decision-support strategy for identifying biomarkers with greater translational potential in heterogeneous cancers such as CCA.
Authors
- Narumon Phaonakrop (ORCID: https://orcid.org/0000-0002-9272-7658)
- Kanawut Kotawong
- Wanna Chaijaroenkul
- Kesara Na-Bangchang
- Sittiruk Roytrakul
Institutions
- Thammasat University (TH)
- National Science and Technology Development Agency (TH)
- National Center for Genetic Engineering and Biotechnology (TH)
Publication Details
- Journal
- Medical Sciences
- Published
- 2026-03-05
- DOI
- https://doi.org/10.3390/medsci14010122
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Research Council of Thailand
- Thailand Science Research and Innovation