The effect of neo-adjuvant chemotherapy with 5-fluorouracil on the integrity of colonic anastomoses: a systematic review and meta-analysis of experimental studies on rats
5FU had a negative impact on the integrity of the anastomotic suture line, as evidenced by lower hydroxyproline levels. Lower bursting pressure and a higher degree of adhesions were found in the 5FU group; however, these results were not statistically significant.
Authors
- В. В. Шепелев (ORCID: https://orcid.org/0000-0001-5135-8115)
- Roman A. Polkin (ORCID: https://orcid.org/0000-0003-4490-3212)
- T. S. Chernyshenko
- Roman Goncharuk
- Maksat Ashyrov
Institutions
- Naval Medical Center San Diego (US)
- Far Eastern Federal University (RU)
Publication Details
- Journal
- Frontiers in Surgery
- Published
- 2026-03-05
- DOI
- https://doi.org/10.3389/fsurg.2026.1737152
- Primary Topic
- Colorectal Cancer Surgical Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministry of Science and Higher Education of the Russian Federation
- Far Eastern Federal University