Burning Issues/Hot Topics: The Charcot Foot

Charcot neuro-osteoarthropathy remains one of the most serious complications of diabetic neuropathy, with the potential for rapid progression to deformity, ulceration and limb-threatening outcomes. The earliest signs and symptoms are often subtle and easily missed, yet early recognition provides a narrow window of opportunity to prevent irreversible structural change. Contemporary diagnostic pathways are underpinned by close clinical observation and correlation of bedside findings with detailed imaging analysis, enabling earlier identification of active disease before collapse occurs. This article provides a comprehensive overview of the Charcot foot, integrating clinical presentation, differential diagnosis and current approaches to investigation and management. It also highlights the challenges of monitoring disease activity over time, including remission and relapse, and the importance of timely specialist referral and multidisciplinary management. By reinforcing structured assessment and targeted intervention, this review aims to support consistent, evidence-informed care for people affected by Charcot neuro-osteoarthropathy.

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Publication Details

Journal
Journal of Clinical Medicine
Published
2026-03-05
DOI
https://doi.org/10.3390/jcm15051993
Primary Topic
Diabetic Foot Ulcer Assessment and Management
Type
article
Field-Weighted Citation Impact
0.00
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article

Burning Issues/Hot Topics: The Charcot Foot

Nina L. Petrova, Ava Khoshnaghsh, Victoria E L Milbourn, Michael E. Edmonds
Journal of Clinical Medicine
Diabetic Foot Ulcer Assessment and Management
article

Burning Issues/Hot Topics: The Charcot Foot

Nina L. Petrova, Ava Khoshnaghsh, Victoria E L Milbourn, Michael E. Edmonds
article en

Abstract

Charcot neuro-osteoarthropathy remains one of the most serious complications of diabetic neuropathy, with the potential for rapid progression to deformity, ulceration and limb-threatening outcomes. The earliest signs and symptoms are often subtle and easily missed, yet early recognition provides a narrow window of opportunity to prevent irreversible structural change. Contemporary diagnostic pathways are underpinned by close clinical observation and correlation of bedside findings with detailed imaging analysis, enabling earlier identification of active disease before collapse occurs. This article provides a comprehensive overview of the Charcot foot, integrating clinical presentation, differential diagnosis and current approaches to investigation and management. It also highlights the challenges of monitoring disease activity over time, including remission and relapse, and the importance of timely specialist referral and multidisciplinary management. By reinforcing structured assessment and targeted intervention, this review aims to support consistent, evidence-informed care for people affected by Charcot neuro-osteoarthropathy.

Journal of Clinical MedicineVol. 15(5)
King's College London (GB), King's College Hospital NHS Foundation Trust (GB), King's College School (GB), Amsterdam University Medical Centers (NL), University of Amsterdam (NL)
Good health and well-being
Openalex Percentile: Top 35%
Diabetic Foot Ulcer Assessment and Management
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