Comparative Effectiveness of Biologic Therapies in Chronic Pouchitis and Crohn’s-Like Disease of the Pouch: A Bi-center Retrospective Cohort Study
In this real-world cohort, ustekinumab was associated with numerically higher long-term clinical response and treatment persistence compared with vedolizumab or adalimumab. These findings support the need for prospective trials to guide biologic selection in chronic pouchitis and Crohn's-like disease of the pouch.
Authors
- Yoav Uchitel
- Nathaniel A. Cohen (ORCID: https://orcid.org/0000-0001-9252-9208)
- Meir Zemel (ORCID: https://orcid.org/0000-0001-9462-2158)
- Benjamin Koslowsky (ORCID: https://orcid.org/0000-0002-6935-6051)
- A Hirsch
- Tzvi Har-Shefi
- Nitsan Maharshak
Institutions
- Tel Aviv University (IL)
- Hebrew University of Jerusalem (IL)
- Tel Aviv Sourasky Medical Center (IL)
- Shaare Zedek Medical Center (IL)
Publication Details
- Journal
- Digestive Diseases and Sciences
- Published
- 2026-03-05
- DOI
- https://doi.org/10.1007/s10620-026-09804-x
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00