Serum proteomics reveals biomarkers for diagnosis, stratification, and mechanistic insights into cerebral microbleeds
This study presents the first comprehensive serum proteomic landscape of CMBs and identifies novel biomarkers with potential for noninvasive early diagnosis and subtype differentiation, supporting precision medicine approaches for CMB management. IGF and MAPK pathway signatures suggest mechanistic links between CMB subtypes and neurovascular aging.
Authors
- An-ming Li
- Xinli Xue
- Hanghang Zhu
- Liu-Chang He
- Wu-meng Yin
- Yu-ming Xu
- Guang-yi Han
- Chang-he Shi
- Yuan Cao
- Lei Zhang
- Yun-chao Wang
Institutions
- Wuhan Prevention and Treatment Center for Occupational Diseases (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2026-03-05
- DOI
- https://doi.org/10.3389/fnagi.2026.1771506
- Primary Topic
- Intracerebral and Subarachnoid Hemorrhage Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China