Direct Oral Anticoagulant Protein Targets and Risk of Cerebral Venous Thrombosis

We found strong genetic evidence linking FXI to CVT pathogenesis and suggestive genetic evidence for FXa and thrombin. Inhibition of these proteins with DOACs may represent an effective therapeutic strategy for CVT.

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Publication Details

Journal
Neurology
Published
2026-03-05
DOI
https://doi.org/10.1212/wnl.0000000000214759
Primary Topic
Cerebral Venous Sinus Thrombosis
Type
article
Field-Weighted Citation Impact
0.00
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article

Direct Oral Anticoagulant Protein Targets and Risk of Cerebral Venous Thrombosis

MARTA PEREZ-ALCANTARA, Iyas Daghlas, D. G. Gill
Neurology
Cerebral Venous Sinus Thrombosis
article

Direct Oral Anticoagulant Protein Targets and Risk of Cerebral Venous Thrombosis

MARTA PEREZ-ALCANTARA, Iyas Daghlas, D. G. Gill
article en

Abstract

We found strong genetic evidence linking FXI to CVT pathogenesis and suggestive genetic evidence for FXa and thrombin. Inhibition of these proteins with DOACs may represent an effective therapeutic strategy for CVT.

NeurologyVol. 106(7)
University of California, San Francisco (US), Sequenom (United Kingdom) (GB), Sequoia (United States) (US), Imperial College London (GB)
Good health and well-being
Openalex Percentile: Top 40%
Cerebral Venous Sinus Thrombosis
DOISourceOpenAlex
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