Outcomes of the three-month weekly isoniazid with rifapentine (3HP) versus the six-month isoniazid preventive therapy (6H) among people newly enrolled in HIV care in western Kenya
We compared 3HP and 6H for TB prevention in people with HIV in western Kenya. 3HP led to better initiation and both had high completion rates. Advanced HIV disease affected participation and non-completers faced significant mortality.
Authors
- Jerphason Mecha (ORCID: https://orcid.org/0009-0008-6446-0395)
- Lilian N. Njagi (ORCID: https://orcid.org/0000-0002-5067-0788)
- Dickens Onyango (ORCID: https://orcid.org/0000-0002-1634-0531)
- Timothy Malika (ORCID: https://orcid.org/0000-0001-5646-4208)
- Sylvia M LaCourse
- Grace John-Stewart
- Samson O Aoro
- John Kinuthia
Institutions
- University of Washington (US)
- Kenyatta National Hospital (KE)
- Kenya Medical Research Institute (KE)
- Great Lakes University of Kisumu (KE)
Publication Details
- Journal
- medRxiv
- Published
- 2026-03-05
- DOI
- https://doi.org/10.64898/2026.03.04.26347621
- Primary Topic
- HIV/AIDS Research and Interventions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Firland Foundation
- Fred Hutchinson Cancer Research Center
- University of Washington
- National Institutes of Health
- Center for AIDS Research, University of Washington