3D imaging and anisotropy mapping of the lamb disc for biomechanical and regenerative insights
This study provides the first full-volume, plane-resolved 3D description of collagen anisotropy in the ovine TMJ disc. The orthotropic fiber architecture and regional anisotropy gradients identified here clarify direction-dependent mechanical behavior and offer quantitative benchmarks for the design of biomimetic scaffolds and regenerative TMJ disc replacements.
Authors
- Andreia Sousa da Silveira (ORCID: https://orcid.org/0000-0002-0205-7321)
- Jussi‐Petteri Suuronen (ORCID: https://orcid.org/0000-0002-1632-761X)
- Ana Prates Soares (ORCID: https://orcid.org/0000-0001-7985-5578)
- Katharina Schmidt‐Bleek (ORCID: https://orcid.org/0000-0002-5719-0867)
- Bernhard Hesse (ORCID: https://orcid.org/0000-0001-9106-8980)
- Timm Weitkamp (ORCID: https://orcid.org/0000-0002-0374-0472)
- Carsten Rendenbach (ORCID: https://orcid.org/0000-0002-9565-7640)
- Paul Helmerking
Institutions
- Synchrotron soleil (FR)
- Humboldt-Universität zu Berlin (DE)
- Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- Frontiers in Physiology
- Published
- 2026-03-05
- DOI
- https://doi.org/10.3389/fphys.2026.1786152
- Primary Topic
- Temporomandibular Joint Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Equipex
- European Commission
- Agence Nationale de la Recherche
- Horizon 2020 Framework Programme