Identification of gene expression signatures associated with neuroinflammation in discogenic sciatica using machine learning and experimental validation
Our findings substantiate the critical roles of <i>KLRK1</i>, <i>LRRK2</i>, <i>NLRP3</i>, and <i>PLG</i> in the neuroinflammation-associated pathogenesis of sciatica, providing pivotal insights into the biological underpinnings of this condition. These neuroinflammatory genes serve as promising targets for advancing therapeutic strategies for sciatica management.
Authors
- Xi-Hong Ye
- Fei Jiang (ORCID: https://orcid.org/0000-0002-2380-1498)
- Ren-Hu Li
- Bin Zheng (ORCID: https://orcid.org/0009-0002-3011-9857)
- Guang-Lei Zhang
- Yang Xu
Institutions
- Hubei University of Arts and Science (CN)
- Xiangyang Central Hospital (CN)
- West Anhui University (CN)
- Lu'an First People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Genetics
- Published
- 2026-03-05
- DOI
- https://doi.org/10.3389/fgene.2026.1666639
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00