Genomic Therapy Matching in Rare and Refractory Cancers

In this cohort study of patients with advanced solid tumors, matching therapies to genomic biomarkers was associated with improved survival only when supported by prospective clinical trial evidence. These findings support using an evidence-based framework to prioritize genomically guided therapies.

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Publication Details

Journal
JAMA Oncology
Published
2026-03-05
DOI
https://doi.org/10.1001/jamaoncol.2026.0127
Primary Topic
Cancer Genomics and Diagnostics
Type
article
Field-Weighted Citation Impact
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article

Genomic Therapy Matching in Rare and Refractory Cancers

Malinda Itchins, Paul Craft, Ian C. Marschner, Keith Thornton et al.
JAMA Oncology
Cancer Genomics and Diagnostics
article

Genomic Therapy Matching in Rare and Refractory Cancers

Malinda Itchins, Paul Craft, Ian C. Marschner, Keith Thornton, Sarah Chinchen, Kathleen Harwood, Katrin Marie Sjoquist, Audrey Silvestri, Lucille Sebastian, Anaiis Zaratzian, Rob King, Clarencia Lie, Rosemary Anne Harrup, Nicola Barrie, Rachael Chang, Hayley P Barker, Paul Leo, Anthony Robert Glover, Hamish S. Scott, Jenny Gu, Michelle M. Cummins, Adrian Pokorny, Julia Dobbins, D. Thomas, Samantha R. Oakes, Amy Prawira, Brett Hughes, A. Mersiades, D. Nicolás Espinoza, James Blackburn, Mark Shackleton, Aaron O'Grady, John Murray, Mark Pinese, E.O. Hajdu, Luke B. Hesson, Mandy L. Ballinger, Erin E. Heyer, Emily Collignon, Michail Charakidis, J. Simes, Paul Liu, Patrick J Wheeler, Geoffrey Peters, Adnan M. Nagrial, Maggie Moore, Ken O’Byrne, Damien Kee, Timothy Humphries, D. Goldstein, M. Zaheed, John P. Grady, Maya Kansara, Cheryll Ye, Vera Terry, Alan McGovern, Tosin Omotoso, Kelly Walwyn, Stephen B. Fox, Michael Millward, Sarah Finlayson, Steven Lane, Michael P. Brown, Andreas W Schreiber, Tharindi Ip, Laura Conole, Prapti Pandya, Christine E. Napier, Gonzalo Tapia-Rico, Melissa Moore, Sachie Pallimulla, Melinda Whelan, David Ross, Min R Qiu, Amelia Mifsud, Hayley Thomas, Australian Molecular Screening and Therapeutic program investigators and contributors, Chee Khoon Lee, Yogita Dheer, Enam Hoque, Vicki Xie, Benhur Amanuel, Frank P. Lin, Chris Karapetis, Nick Ristevski, Peter Grimison, Subotheni Thavaneswaran, Isabella Richardson, Craig Underhill, Sagun Parakh, Rachael Morton, Kelly Nicholas, Jayesh Desai, Mark J. Cowley
article en

Abstract

In this cohort study of patients with advanced solid tumors, matching therapies to genomic biomarkers was associated with improved survival only when supported by prospective clinical trial evidence. These findings support using an evidence-based framework to prioritize genomically guided therapies.

JAMA Oncology
South Australia Pathology (AU), Edith Cowan University (AU), The University of Sydney (AU), Royal Adelaide Hospital (AU), Australian Research Council (AU), Garvan Institute of Medical Research (AU), Queensland University of Technology (AU), University of South Australia (AU), The University of Western Australia (AU), Walter and Eliza Hall Institute of Medical Research (AU), Peter MacCallum Cancer Centre (AU), Princess Alexandra Hospital (AU), Northern Hospital (AU), Canberra Hospital (AU), Royal Hobart Hospital (AU), UNSW Sydney (AU), Cooperative Trials Group for Neuro-Oncology (AU), Queen Elizabeth II Medical Centre (AU), Chris O’Brien Lifehouse (AU), National Breast Cancer Foundation (AU), Prince of Wales Hospital (AU), Children's Cancer Institute Australia (AU), St George Hospital (AU), Alice Springs Hospital (AU), Royal Darwin Hospital (AU), Centre for Cancer Biology (AU), The Kinghorn Cancer Centre (AU), Linear Clinical Research (AU), Pathwest Laboratory Medicine (AU), Austin Health (AU), National Health and Medical Research Council (AU)
Good health and well-being
Openalex Percentile: Top 33%
Cancer Genomics and Diagnostics
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