Crosstalk of cancer stemness-neutrophils in outcome of intracranial germ cell tumors

Our study demonstrates that the interaction between neutrophils and stemness contributes to the malignant progression of iGCTs, leading to adverse clinical outcomes. These findings not only advance our understanding of iGCT biology but also highlight potential novel therapeutic targets. Moreover, they provide a rationale for developing immunotherapy strategies aimed at modulating the neutrophil-stemness axis in iGCTs.