<scp> <i>Grifola frondosa</i> </scp> polysaccharide ameliorates adenine‐induced <scp>CKD</scp> by inhibiting <scp>TGF</scp> ‐β1/Smad signaling pathway in mice
Our findings demonstrated that GFP exerted potent renoprotection against adenine-induced CKD in mice, mediated by its antioxidant, anti-inflammatory, and anti-fibrotic activities. The anti-fibrotic mechanism was mediated via the suppression of the TGF-β1/Smad signaling pathway. These results highlighted the potential of GFP as functional food ingredients or adjunctive therapeutic agents for preventing and treating CKD and its complications. © 2026 Society of Chemical Industry.
Authors
- Chao Wu (ORCID: https://orcid.org/0000-0002-6193-4398)
- Huanjun Shi
- Lian Shi
- Le Jia
- Jianjun Zhang
Institutions
- Shandong Agricultural University (CN)
Publication Details
- Journal
- Journal of the Science of Food and Agriculture
- Published
- 2026-03-05
- DOI
- https://doi.org/10.1002/jsfa.70564
- Primary Topic
- Fungal Biology and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00