Subclonal Complete Loss of <i>CDKN1B</i> as a Common Genomic Alteration in Prostate Cancer: Associations with Race and Prostate Cancer Outcomes
Subclonal biallelic loss of <i>CDKN1B</i> resulting in complete p27 protein loss is one of the most commonly occurring biallelic tumor suppressor genomic alterations in primary prostate cancer, and could contribute to worse prostate cancer outcomes, specifically in AA males.
Authors
- Karen S. Sfanos (ORCID: https://orcid.org/0000-0002-7015-3059)
- Luke Mummert (ORCID: https://orcid.org/0000-0002-1128-9167)
- Jiayun Lu (ORCID: https://orcid.org/0000-0002-5592-6658)
- Tamara L Lotan
- Yuezhou Jing
- Julia Flores
- Jessica Hicks
- Rebecca Morton
Institutions
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
- Sidney Kimmel Comprehensive Cancer Center (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-03-05
- DOI
- https://doi.org/10.64898/2026.03.03.709424
- Primary Topic
- Cancer-related Molecular Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00