Plasma regulates homeostatic pulmonary endothelial signaling to mitigate vascular leak following polytrauma and hemorrhagic shock
FFP resuscitation after PT/HS reduces systemic inflammation and preserves pulmonary vascular barrier function, potentially through promotion of mitochondrial signaling, metabolic recovery, and endothelial stress regulation.
Authors
- Taylor E. Wallen (ORCID: https://orcid.org/0000-0003-2671-7168)
- Delores A. Stacks (ORCID: https://orcid.org/0000-0002-3824-0953)
- Melad Dababneh (ORCID: https://orcid.org/0009-0008-9877-3891)
- J Richter (ORCID: https://orcid.org/0000-0002-6951-6633)
- G Vollmer
- Krystal L Rivera-Figueroa
- Lei Zheng
- Camilla Margaroli
Institutions
- University of Alabama at Birmingham (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-03-04
- DOI
- https://doi.org/10.64898/2026.03.04.709561
- Primary Topic
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Type
- article
- Field-Weighted Citation Impact
- 0.00