Matrix viscoelasticity regulates dermal fibroblast activation in a three-dimensional fibrillar microenvironment

Our results demonstrate that fibroblast activation is highly responsive to matrix stress relaxation rate, and that models incorporating fibrillar, viscoelastic networks can provide new insights into the role of ECM mechanics driving fibroblast activation.

Authors

Institutions

Publication Details

Journal
bioRxiv (Cold Spring Harbor Laboratory)
Published
2026-03-04
DOI
https://doi.org/10.64898/2026.03.02.709111
Primary Topic
Cellular Mechanics and Interactions
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Matrix viscoelasticity regulates dermal fibroblast activation in a three-dimensional fibrillar microenvironment

Gianna Gathman, M Patel, Ryan S Stowers, Daniella Isabel Walter
bioRxiv (Cold Spring Harbor Laboratory)
Cellular Mechanics and Interactions
article

Matrix viscoelasticity regulates dermal fibroblast activation in a three-dimensional fibrillar microenvironment

Gianna Gathman, M Patel, Ryan S Stowers, Daniella Isabel Walter
article en

Abstract

Our results demonstrate that fibroblast activation is highly responsive to matrix stress relaxation rate, and that models incorporating fibrillar, viscoelastic networks can provide new insights into the role of ECM mechanics driving fibroblast activation.

bioRxiv (Cold Spring Harbor Laboratory)
University of California, Santa Barbara (US)
Openalex Percentile: Top 35%
Cellular Mechanics and Interactions
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.

Matrix viscoelasticity regulates dermal fibroblast activation in a three-dimensional fibrillar microenvironment — Gianna Gathman, M Patel, et al. · bioRxiv (Cold Spring Harbor Laboratory) (2026) | TGRS Research Map | TGRS