Loneliness, Anxiety Symptoms, Depressive Symptoms, and Suicidal Ideation in the All of Us Dataset
In this cross-sectional study of 62 685 participants from the All of Us Research Program, loneliness partially mediated the association between anxiety symptoms and suicidal ideation as well as depressive symptoms and suicidal ideation. Targeting and reducing loneliness may present a transdiagnostic approach to arrest the progression from anxiety and depressive symptoms toward suicidal ideation.
Authors
- Jacob Franklin
- Colin G. Walsh (ORCID: https://orcid.org/0000-0002-9379-2056)
- Katherine Musacchio Schafer (ORCID: https://orcid.org/0000-0002-3744-1518)
- Peter Embi
Institutions
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- JAMA Network Open
- Published
- 2026-03-04
- DOI
- https://doi.org/10.1001/jamanetworkopen.2026.0596
- Primary Topic
- Suicide and Self-Harm Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Patient-Centered Outcomes Research Institute
- Agency for Healthcare Research and Quality