Discoidin Domain Receptor 1 Promotes Myocardial Fibrosis by Suppressing Specificity Protein 1 Ubiquitination and Degradation in Male Spontaneously Hypertensive Rats
In summary, this study demonstrates that DDR1 is a pivotal driver of MF progression, establishing both a theoretical foundation and an experimental basis for DDR1-targeted therapy in MF.
Authors
- Hang Yin (ORCID: https://orcid.org/0000-0003-3526-6901)
- Chuanbao Li
- Rui Tian
- Yuguo Chen
- Dazhou Lu
- Zerui Wang
- Feng Xu
- Xiaoxing Li
Institutions
- Qilu Hospital of Shandong University (CN)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2026-03-04
- DOI
- https://doi.org/10.1161/jaha.125.043251
- Primary Topic
- Cell Adhesion Molecules Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00