Risks of non-breast, non-ovarian cancers for BRCA1 and BRCA2 pathogenic variant carriers: a prospective cohort study

Apart from pancreatic, prostate, and possibly stomach cancers for BRCA2 PV carriers, and possibly pancreatic cancer for BRCA1 PV carriers, there is no evidence that BRCA1 and BRCA2 PV carriers have substantially increased risks of other non-breast, non-ovarian cancers. Our prospective risk estimates are informative for cancer risk assessment for people with BRCA1 and BRCA2 PVs.

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Publication Details

Journal
BMC Medicine
Published
2026-03-04
DOI
https://doi.org/10.1186/s12916-026-04753-8
Primary Topic
BRCA gene mutations in cancer
Type
article
Field-Weighted Citation Impact
0.00
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article

Risks of non-breast, non-ovarian cancers for BRCA1 and BRCA2 pathogenic variant carriers: a prospective cohort study

R. Yang, J Hopper, E. F. Ross, Shuai Li et al.
BMC Medicine
BRCA gene mutations in cancer
article

Risks of non-breast, non-ovarian cancers for BRCA1 and BRCA2 pathogenic variant carriers: a prospective cohort study

R. Yang, J Hopper, E. F. Ross, Shuai Li, Sarah Colonna, Whitney F. Maxwell, K. Phillips, R L Milne, Tu Nguyen-Dumont, Jeanine M. Genkinger, Melissa C. Southey, Mary Beth Terry, Esther M. John, Mary Daly, Irene L. Andrulis, Allison W. Kurian, Robert J. MacInnis
article en

Abstract

Apart from pancreatic, prostate, and possibly stomach cancers for BRCA2 PV carriers, and possibly pancreatic cancer for BRCA1 PV carriers, there is no evidence that BRCA1 and BRCA2 PV carriers have substantially increased risks of other non-breast, non-ovarian cancers. Our prospective risk estimates are informative for cancer risk assessment for people with BRCA1 and BRCA2 PVs.

BMC Medicine
Fox Chase Cancer Center (US), The University of Melbourne (AU), University of Toronto (CA), Cancer Council Victoria (AU), Peking University (CN), Lunenfeld-Tanenbaum Research Institute (CA), University of Utah (US), Columbia University Irving Medical Center (US), Peter MacCallum Cancer Centre (AU), Huntsman Cancer Institute (US), Silent Spring Institute (US), Monash Health (AU), Temple University Health System (US), Sinai Health System (CA), Monash University (AU), Columbia University (US), Stanford University (US)
Good health and well-being
Openalex Percentile: Top 34%
BRCA gene mutations in cancer
DOIOpen Access PDFOpenAlex
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