Spatial Transcriptomics Reveals Location-Specific Tumor Cell Subtypes and Signaling within Multifocal Small Intestinal Neuroendocrine Tumors
While further validation is needed, our findings indicate that multifocal SI-NETs consist of spatially distinct tumor cell subtypes affected by local cellular interactions, providing insight into SI-NET intra-tumoral heterogeneity, possible microenvironmental-triggered tumorigenesis, and potential subtype-targeted therapeutic strategies.
Authors
- Netta Mäkinen (ORCID: https://orcid.org/0000-0003-0104-7794)
- Akitada Yogo (ORCID: https://orcid.org/0000-0002-7434-6974)
- Naoki Akanuma (ORCID: https://orcid.org/0000-0002-4165-1550)
- Grace Kim (ORCID: https://orcid.org/0000-0003-4603-9448)
- Chrissie Thirlwell
- Eric Nakakura
Institutions
- Chiba University (JP)
- University of California, San Francisco (US)
- University of Bristol (GB)
- Dana-Farber Cancer Institute (US)
- University of San Francisco (US)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2026-03-04
- DOI
- https://doi.org/10.1158/1078-0432.ccr-25-2854
- Primary Topic
- Neuroendocrine Tumor Research Advances
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Neuroendocrine Tumor Research Foundation
- Broad Institute
- University of California, San Francisco