Huanggan decoction ameliorates cholestatic hepatic fibrosis in rats via TGF-β1/Smad3 signaling pathway
Findings suggest that HGD demonstrated a remarkable liver-protective effect, potentially linked to halting liver fibrosis progression by maintaining the equilibrium between MMP1 and TIMP1, modulating TGF-β1/Smad signal pathway, suppressing HSC activation, and exhibiting anti-inflammatory characteristics.
Authors
- Jianhong Yang (ORCID: https://orcid.org/0000-0003-3939-6471)
- Xueli Ma
- Yaya Lei
- Xiaohui Jin
- Yanping He
- Ting Gao
- Yuna Zhao
- Jing Chen
Institutions
- Ningxia Medical University (CN)
- Ningxia Medical University General Hospital (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2026-03-04
- DOI
- https://doi.org/10.1371/journal.pone.0344168
- Primary Topic
- Liver physiology and pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00