Assessment of Homologous Recombination System Gene Expression in Chemologically Induced Carcinogenesis In Vivo Models
Our findings confirm that MC and TCA influence tumor formation and reveal that suppression of homologous recombination genes may contribute to this process. In addition, it has been established that as tumors progress, the expression of DNA repair genes declines and aberrant gene states accumulate. These data emphasize the importance of studying the state of DNA repair genes for the development of more effective strategies for cancer diagnosis and therapy.
Authors
- М.М. Цыганов
- Irina Aleksandrovna Tsydenova (ORCID: https://orcid.org/0000-0002-2716-3075)
- Anastasia Fedorenko
- Dmitry M. Loos
- Sofia S. Timoshenko (ORCID: https://orcid.org/0009-0002-2409-6353)
- Zhansaya Sharipkhanova
- Pavel E. Nikiforov
- Danna Zh. Bulatova
- Marina K. Ibragimova (ORCID: https://orcid.org/0000-0001-8815-2786)
- Aigerim A. Bayanbayeva
Institutions
- Siberian State Medical University (RU)
- Tomsk National Research Medical Center (RU)
- Research Institute of Pharmacology and Regenerative Medicine named ED Goldberg (RU)
Publication Details
- Journal
- Current Issues in Molecular Biology
- Published
- 2026-03-04
- DOI
- https://doi.org/10.3390/cimb48030275
- Primary Topic
- DNA Repair Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00