SIRT1 regulates glycolysis and angiogenesis of ovarian cancer through β-catenin/c-Myc/PKM2, and its mechanism in chemotherapy resistance
SIRT1 promotes glycolysis and angiogenesis of ovarian cancer cells by activating β-catenin/c-myc/PKM2 pathway, thus enhancing chemotherapy resistance. SIRT1 is expected to be a new target for ovarian cancer treatment.
Authors
- Deng He (ORCID: https://orcid.org/0000-0002-1669-1729)
- Yu Zhou (ORCID: https://orcid.org/0000-0001-5999-7966)
- Juan Zhang (ORCID: https://orcid.org/0000-0001-6241-7176)
- Hu Wang (ORCID: https://orcid.org/0009-0009-9026-9751)
- Chengju Zhang
- Shangqi Ni
- Xi Wang
- Tiantian Feng
Institutions
- North Sichuan Medical University (CN)
- Affiliated Hospital of North Sichuan Medical College (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2026-03-04
- DOI
- https://doi.org/10.3389/fonc.2026.1762850
- Primary Topic
- Sirtuins and Resveratrol in Medicine
- Type
- article
- Field-Weighted Citation Impact
- 0.00