Optimized RTX strategy plus structured glucocorticoid tapering for primary membranous nephropathy: a multicenter propensity score-matched cohort study
In this propensity score-matched multicenter cohort, an exposure-optimized strategy combining interval RTX dosing, structured glucocorticoid tapering, and TDM-guided redosing was associated with higher and earlier remission, deeper immunologic response, and lower relapse compared with the standard RTX monotherapy.
Authors
- Min Wu (ORCID: https://orcid.org/0000-0001-5462-6920)
- Huimin Xia (ORCID: https://orcid.org/0000-0002-0103-1672)
- Jiayi Liu (ORCID: https://orcid.org/0000-0003-1819-2998)
- Biao Huang
- Yuxia Zhang
- Yao Sun
- Qing Yin
- Ziyu Liang
- Yujia Wang
- Yanting Yu
- Ri-Ning Tang
Institutions
- Zhejiang Sci-Tech University (CN)
- Southeast University (BD)
- Nanjing Drum Tower Hospital (CN)
Publication Details
- Journal
- Frontiers in Molecular Biosciences
- Published
- 2026-03-04
- DOI
- https://doi.org/10.3389/fmolb.2026.1770916
- Primary Topic
- Renal Diseases and Glomerulopathies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Jiangsu Commission of Health
- National Natural Science Foundation of China
- Southeast University
- Nanjing Drum Tower Hospital