Immunoreactivity of pan MHC-I epitopes on Crimean-Congo hemorrhagic fever virus glycoprotein C-terminal
This study provides a systematic framework for identifying conserved and immunogenic pan-MHC-I-restricted epitopes within the CCHFV Gc protein. The validated candidates may support the rational design of multi-epitope vaccines and contribute to understanding cellular immune responses against CCHFV.
Authors
- Baozeng Sun (ORCID: https://orcid.org/0009-0005-3892-7359)
- Shuya Yang (ORCID: https://orcid.org/0000-0001-8884-7254)
- Dongbo Jiang (ORCID: https://orcid.org/0000-0002-2675-5634)
- Fu Zj
- Yun Zhang (ORCID: https://orcid.org/0000-0002-2636-8394)
- Jin Li (ORCID: https://orcid.org/0000-0002-6131-456X)
- Zilu Ma
- Yuanjie Sun
- Yusi Zhang
- Yulin Yang
- Yongkai Wang
- Chunmei Zhang
- Enqi Guan
- Yubo Sun
- Linfeng Cheng
- Yanbo Wang
- Zhenchi Fang
- Haobo Kang
- Kun Yang
Institutions
- Shanghai Changzheng Hospital (CN)
- JiangSu Armed Police General Hospital (CN)
- Beijing Radiation Center (CN)
- Tang Du Hospital (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-03-04
- DOI
- https://doi.org/10.3389/fimmu.2026.1693892
- Primary Topic
- vaccines and immunoinformatics approaches
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Yakult Bio-Science Foundation
- Key Research and Development Projects of Shaanxi Province