Association of Changes in Activity Patterns With Brain Atrophy and Disability Progression in People With Multiple Sclerosis
Within-person reductions in daytime activity patterns precede clinical disability worsening and brain atrophy in PwMS. Although results require confirmation and thresholds of and responsiveness to change need to be established, longitudinal accelerometry may offer sensitive, noninvasive biomarkers of subclinical disease.
Authors
- Alice Delaney
- Nicole Bou Rjeily (ORCID: https://orcid.org/0000-0002-1187-5262)
- Blake E Dewey
- Alexandra Zambriczki Lee
- Muraleetharan Sanjayan (ORCID: https://orcid.org/0009-0006-6465-0063)
- Yasser Fadlallah (ORCID: https://orcid.org/0009-0001-6806-1841)
- Chelsea Wyche
- Safiya Duncan
- Peter A. Calabresi
- Ellen M. Mowry
- Pratim Guha Niyogi
- Kathryn C. Fitzgerald
- Vadim Zipunnikov
Institutions
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
Publication Details
- Journal
- Neurology
- Published
- 2026-03-04
- DOI
- https://doi.org/10.1212/wnl.0000000000214678
- Citations
- 1
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 36.00