Neonatal pulmonary vascular remodeling induced by increased blood flow is associated with an antiviral-like immune signature
We provide the direct experimental evidence that neonatal IPF alone is sufficient to drive pulmonary small vessel remodeling. The process is fundamentally mediated by an activated immune response characterized by an antiviral-like signature, a mechanism distinct from those reported in classic adult PAH models. This novel model offers a critical platform for investigating the developmental-specific pathogenesis of pediatric PAH and bridging the translational "valley of death."
Authors
- Sixie Zheng (ORCID: https://orcid.org/0000-0001-6603-7947)
- Jiapei Wang (ORCID: https://orcid.org/0000-0002-5412-790X)
- Lincai Ye (ORCID: https://orcid.org/0000-0001-8808-2810)
- Yi-Xiang Wang (ORCID: https://orcid.org/0000-0002-4021-4228)
- Siqi She
- Debao Li
- Yiting Xue
- Hao Li
- Yuqing Hu
Institutions
- Ningbo University (CN)
- Shanghai Children's Medical Center (CN)
- Ningbo University Affiliated Hospital (CN)
- Children's Hospital of Fudan University (CN)
- Shanghai Children's Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-03-04
- DOI
- https://doi.org/10.3389/fimmu.2026.1780303
- Primary Topic
- Pulmonary Hypertension Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00