Broad innate immune activation enhances the protective efficacy of rBCG-LTAK63 against Mycobacterium tuberculosis
This demonstrates that protection is achieved in a diminished innate inflammatory response scenario, but its full engagement can further reduce pulmonary bacterial loads. Together, these findings demonstrate that rBCG-LTAK63 enhances protection against TB through a broad innate activation including inflammasome-associated mechanisms.
Authors
- Nancy Starobinas (ORCID: https://orcid.org/0000-0001-5716-3394)
- Ana Carolina de Oliveira Carvalho
- Paulo Henrique Santana Silveira (ORCID: https://orcid.org/0000-0003-0263-2901)
- Alex Issamu Kanno
- Sergio Costa Oliveira
- Lázaro Moreira Marques-Neto
- Dunia Rodriguez
- Monalisa Martins Trentini
- Luciana Cezar de Cerqueira Leite
Institutions
- Universidade de São Paulo (BR)
- Instituto Butantan (BR)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-03-04
- DOI
- https://doi.org/10.3389/fimmu.2026.1758476
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Fundação Butantan