Exploring the neuroprotective mechanism of Tongqiao Huashuan granules in vascular dementia based on PLCγ1/IP3R signaling pathway
The neuroprotective effect of TQHS granules on experimental VaD may be mediated by regulating the PLCγ1/IP3R pathway, improving oxidative stress injury and intracellular calcium overload in VaD. TQHS granules hold considerable promise as a viable complementary intervention capable of retarding the neurodegenerative trajectory of VaD.
Authors
- Yanna Ren (ORCID: https://orcid.org/0000-0001-8732-5753)
- Dingding Liu (ORCID: https://orcid.org/0000-0002-8724-036X)
- Jiayi Liu (ORCID: https://orcid.org/0000-0003-1819-2998)
- Tong Lei
- Liping Cao
- Jing Cai
- Yuanhua Wu
- Xianhui Huang
Institutions
- Guiyang College of Traditional Chinese Medicine (CN)
- The First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine (CN)
- Affiliated Hospital of Guizhou Medical University (CN)
- China Academy of Chinese Medical Sciences (CN)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2026-03-04
- DOI
- https://doi.org/10.3389/fnagi.2026.1719664
- Primary Topic
- Neurological Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Guizhou University