Genomic and chemical analyses of 713 marine biofilm-derived bacterial strains

Marine microorganisms are important sources of natural products, yet quite a few studies have systematically explored the production of active molecules by marine biofilm-associated bacteria. In the present study, we analyzed nearly complete genomes of 713 strains isolated from marine biofilms to assess their biosynthetic potential. We further conducted experiments to discover compounds with a strong inhibitory effect against pathogenic bacterial strains. This work has laid the groundwork for further prospecting marine biofilm-associated bacterial strains for antibacterial agents.