Leveraging PANoptosis-associated genes for unraveling implication of decidualization deficiency in pre-eclampsia via transcriptome data and experiment validation
This study suggests a potential association between PANoptosis-related molecular dysregulation and decidualization deficiency in PE. The identified PANoptosis-related signature genes may serve as candidate biomarkers with predictive relevance, and melatonin may represent a potential therapeutic candidate targeting PANoptosis-related pathways. These findings provide a foundation for future mechanistic and translational studies on PE.
Authors
- Yuepeng Jiang (ORCID: https://orcid.org/0000-0002-1444-7183)
- Yiming Ma (ORCID: https://orcid.org/0000-0002-4654-5642)
- Aiwu Huang
- Yang Yan (ORCID: https://orcid.org/0000-0002-2663-287X)
- Xinyu Zhao (ORCID: https://orcid.org/0000-0002-5128-4424)
- Qingnan Fan
- Hongli Zhao
- Yang Zhao
- Hongying Tang
- Meiping Ding
- Yuanyuan Zhang
Institutions
- Macau University of Science and Technology (MO)
- Zhejiang Chinese Medical University (CN)
- Nanjing University of Chinese Medicine (CN)
- Jiangmen Wuyi Traditional Chinese Medicine Hospital (CN)
- County Hospital (GB)
- Hangzhou Hospital of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2026-03-04
- DOI
- https://doi.org/10.3389/fcell.2026.1677798
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Strong
- National Natural Science Foundation of China
- Zhejiang Chinese Medical University
- Medical Scientific Research Foundation of Zhejiang Province, China
- Natural Science Foundation of Zhejiang Province