Effect of inspired oxygen fraction during anesthesia on inflammation and antioxidant enzyme activity in the mouse cortex and hippocampus

Only 80% oxygen increased hippocampal IL-1β compared with controls, suggesting region-specific vulnerability to oxygen-induced neuroinflammation. However, no significant differences between FiO₂ levels (30% vs. 80%) indicate a limited neuroinflammatory impact under 3 h of anesthesia. Further studies with longer exposure and surgical conditions are needed to clarify the clinical implications.

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Publication Details

Journal
Frontiers in Aging Neuroscience
Published
2026-03-04
DOI
https://doi.org/10.3389/fnagi.2026.1761281
Primary Topic
Anesthesia and Neurotoxicity Research
Type
article
Field-Weighted Citation Impact
0.00

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article

Effect of inspired oxygen fraction during anesthesia on inflammation and antioxidant enzyme activity in the mouse cortex and hippocampus

Elliot H. Lee, Soo-Jin Oh, Jee-Eun Chang, Jin-Young Hwang
Frontiers in Aging Neuroscience
Anesthesia and Neurotoxicity Research
article

Effect of inspired oxygen fraction during anesthesia on inflammation and antioxidant enzyme activity in the mouse cortex and hippocampus

Elliot H. Lee, Soo-Jin Oh, Jee-Eun Chang, Jin-Young Hwang
article en

Abstract

Only 80% oxygen increased hippocampal IL-1β compared with controls, suggesting region-specific vulnerability to oxygen-induced neuroinflammation. However, no significant differences between FiO₂ levels (30% vs. 80%) indicate a limited neuroinflammatory impact under 3 h of anesthesia. Further studies with longer exposure and surgical conditions are needed to clarify the clinical implications.

Frontiers in Aging NeuroscienceVol. 18
SNUH SMG-SNU Boramae Medical Center (KR), Korea Institute of Brain Science (KR), Korea Institute of Science and Technology (KR)
National Research Foundation, Korea Institute of Science and Technology, National Research Foundation of Korea, Ministry of Science and ICT, South Korea
Openalex Percentile: Top 48%
Anesthesia and Neurotoxicity Research
DOIOpen Access PDFOpenAlex
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