Editorial: Gene editing in cancer gene therapy

Gene editing technologies have rapidly evolved from experimental tools into promising therapeutic strategies in oncology. Advances in programmable nucleases, epigenome-targeting approaches, and delivery systems are reshaping how cancer is studied and treated. This Research Topic, Gene Editing in Cancer Gene Therapy, brings together five complementary contributions- Collectively, these five contributions portray gene editing in cancer therapy as an integrated continuum, from epigenetic regulation and immune modulation to delivery technologies, clinical genomics, and policy frameworks. Rather than focusing on a single technology, this Research Topic highlights the inherently interdisciplinary nature of gene editing and its expanding role in precision oncology.We hope that this Research Topic will serve as a valuable resource for researchers and clinicians seeking to understand the evolving landscape of gene editing in oncology, and that it will stimulate further interdisciplinary efforts bridging molecular engineering, cancer biology, and translational medicine.1.Zhang R, Yao T, Fan M, Jiang X, Wang K, Cui M, Bing K, Xia X. Precision scalpels for the epigenome: next-gen editing tools in targeted therapies. Front Med 2025; 12:1613722.