Progression of bone and joint space deformity in patients with mild knee osteoarthritis: Data from the IMI-APPROACH cohort
Substantial intra-articular joint and bone varus progression was observed within two years. This study shows that bone deformity is to some extent a dynamic process and there is a growing varus malalignment in the intra-articular knee joint and bones. Thereby this study emphasizes the importance of leg malalignment for progression of intra-articular knee joint changes in early OA.
Authors
- Nienke van Egmond (ORCID: https://orcid.org/0000-0003-1294-8408)
- Eva Bax (ORCID: https://orcid.org/0000-0003-3892-6987)
- Tim F Cootes
- Roel J.H. Custers (ORCID: https://orcid.org/0000-0001-5253-2883)
- Harrie Weinans (ORCID: https://orcid.org/0000-0002-2275-6170)
- Hassan Rayegan
- Francis Berenbaum
- Ida K. Haugen
- Mylène P. Jansen
- Francisco J. Blanco
- Ruurd J.A. Kuiper
- Vahid Arbabi
- Margreet Kloppenburg
- Willem Paul Gielis
- Simon C. Mastbergen
- H Nguyen (9597434)
- Ralph J.B. Sakkers
Institutions
- Inserm (FR)
- Leiden University Medical Center (NL)
- University Medical Center Utrecht (NL)
- Sorbonne Université (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Iranshahr University (IR)
- Diakonhjemmet Hospital (NO)
- Centre de Recherche Saint-Antoine (FR)
- Complexo Hospitalario Universitario A Coruña (ES)
- Health Data Research UK (GB)
- Instituto de Investigación Biomédica de A Coruña (ES)
- University of Birjand (IR)
- Delft University of Technology (NL)
Publication Details
- Journal
- Osteoarthritis and Cartilage Open
- Published
- 2026-03-05
- DOI
- https://doi.org/10.1016/j.ocarto.2026.100762
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00