Sex-Specific Associations of α-Synuclein Pathology With Tau Accumulation
In this cohort study of participants across the Alzheimer disease continuum, α-synuclein copathology was associated with faster tau accumulation in women than men. These findings may inform sex-specific interpretation of α-synuclein biomarkers and trial design.
Authors
- Scott A. Przybelski (ORCID: https://orcid.org/0009-0009-3437-3773)
- Matthew L. Senjem (ORCID: https://orcid.org/0000-0001-9308-9275)
- Elijah Mak (ORCID: https://orcid.org/0000-0002-6437-8024)
- Angela J. Fought (ORCID: https://orcid.org/0000-0002-7486-8596)
- Rocca Wa
- Heather J. Wiste (ORCID: https://orcid.org/0009-0002-8833-2693)
- Paul Aisen
- Andrew J. Saykin
- Clifford R. Jack
- Bradley F. Boeve
- Arthur W. Toga
- Richard J. Perrin
- Alzheimer’s Disease Neuroimaging Initiative
- Christopher G. Schwarz
- Val J. Lowe
- Robert I. Reid
- Michael W. Weiner
- Ronald C. Petersen
- Prashanthi Vemuri
- Kejal Kantarci
- Laurel Beckett
Institutions
- Mayo Clinic (US)
- Alzheimer’s Disease Neuroimaging Initiative (US)
- Mayo Clinic in Florida (US)
Publication Details
- Journal
- JAMA Network Open
- Published
- 2026-03-04
- DOI
- https://doi.org/10.1001/jamanetworkopen.2026.0461
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00