Sustained symptom relief and safety over five years following a single intra-articular injection of 2.5[%] polyacrylamide hydrogel in patients with knee osteoarthritis

A single IA injection of iPAAG was associated with sustained improvements in pain and function, with a favourable safety profile maintained through 5 years. These observational data support iPAAG as a promising long-acting, non-surgical treatment option for knee OA.