Chrysopogon zizanioides (Vetiver) Essential Oil from Qatar Targets AKT1 and STAT3 in Colorectal and Lung Cancer: GC-MS Profiling, In Vitro Antiproliferative Activity, and In Silico Analyses
CZEO from Qatar exhibits potent antiproliferative activity against colorectal and lung cancer cells, supported by a sesquiterpenoid-rich phytochemical profile. Integrative computational analyses highlight AKT1 and STAT3 as key molecular targets, with rosifoliol and α-vetivone emerging as promising lead compounds. These findings support CZEO as a natural, multi-target anticancer agent, warranting further mechanistic and in vitro and in vivo validation.
Authors
- Muhammad Suleman (ORCID: https://orcid.org/0000-0003-2914-1862)
- Samah Mechmechani (ORCID: https://orcid.org/0000-0002-3320-6684)
- Abdullah A. Shaito (ORCID: https://orcid.org/0000-0003-3524-7962)
- Layal Karam (ORCID: https://orcid.org/0000-0002-6970-0174)
- Aseela Fathima
- Diana C. G. A. Pinto
- Haritha Kalath
- Hadi M. Yassine
- Mai M. Karousa
- Maha M. Ayoub
- M. Angelica M. Rocha
Institutions
- Rede de Química e Tecnologia (PT)
- Qatar University (QA)
- University of Aveiro (PT)
Publication Details
- Journal
- Plants
- Published
- 2026-03-04
- DOI
- https://doi.org/10.3390/plants15050784
- Primary Topic
- Essential Oils and Antimicrobial Activity
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Universidade de Aveiro
- Qatar University
- Ministério da Ciência, Tecnologia e Ensino Superior
- Qingdao University of Science and Technology
- Rede de Química e Tecnologia
- Laboratório Associado para a Química Verde
- Fundação para a Ciência e a Tecnologia