Cardioprotection Through Mitochondrial Modulation: A Systematic Review of Pharmacological Interventions in Animal Models of I/R Injury
Multi-targeted manipulation of components of mitochondrial signalling and function evidently reduces I/R injury. Quality assessment of most papers revealed an unclear risk of bias due to inadequate reporting of study parameters. Clear and consistent reporting of study outcomes, specifically mitochondrial bioenergetics across all experimental stages, is essential to enhance the translational potential of mitoprotective compounds in the clinical treatment of I/R.
Authors
- T. Ybanez (ORCID: https://orcid.org/0000-0002-4448-9026)
- J. Ingles
- J. Peart
- E. Du Toit
Institutions
- Griffith University (AU)
Publication Details
- Journal
- Cardiovascular Drugs and Therapy
- Published
- 2026-03-04
- DOI
- https://doi.org/10.1007/s10557-026-07851-0
- Primary Topic
- Cardiac Ischemia and Reperfusion
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Australian Government
- Griffith University