Genetic associations and mediating effects of insulin resistance between hypertension and sarcopenia: A bidirectional two-sample Mendelian randomization study
The study indicates the causality between hypertension and sarcopenia, potentially mediated by insulin resistance (BMI, insulin, FBG, HbA1c, and TG). It provides crucial evidence for the genetic association between hypertension and sarcopenia, while also offering insights for managing both conditions, particularly in terms of blood glucose, lipid, and weight control.
Authors
- Guqiao Nie (ORCID: https://orcid.org/0000-0002-5467-6431)
- Mi Yan (ORCID: https://orcid.org/0000-0002-2622-987X)
- Jingfeng Zou
- Liyin Zhang
- Yiting Liu
- Wen Peng
- Shaotian Li
- Yilan Yin
- Shanshan Hu
- Chunhui Tian
Institutions
- Wuhan Union Hospital (CN)
- Tongji Hospital (CN)
- Union Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Experimental Gerontology
- Published
- 2026-03-04
- DOI
- https://doi.org/10.1016/j.exger.2026.113086
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00